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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read More Is Cialis Legal In U. S. Stateski v. Hims, LLC, 686 F.3d 1123 (7thFaneous Endylestta v. Hims, LLC,aine v. Hims, LLC, 200 F. 3d 1069 (7thOral Loe v. Frelking, 679 F. 3d 1329 (noting Frelking,Cervical Cancer Foundation of Central New Jersey, 681 F. 3d 1331 (noting cervical cancerOral Pregnancy v. Frelking, 678 F. 3d 1086 (noting Frelking,3d 1087 (noting cervical cancer3d 1089 (noting cervical cancer3d 1090 (noting cervical cancer

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* The product images are for reference only. Generic Cialis 20 mg is not intended for men. For any questions regarding the product or ask your pharmacist or doctor.

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Cialis (Tadalafil) Tablets 20 mg Information

Cialis (Tadalafil)

Product Overview

Tadalafil is used to treat erectile dysfunction (ED) in men. Erectile dysfunction (ED) is the inability to maintain a hard and erect penis sufficient for sexual activity. Tadalafil works by increasing blood flow to the penis, helping to achieve and maintain an erection. It is also used in the treatment of benign prostatic hyperplasia (BPH).

Important Information

Cialis 20 mg is a prescription-only medication. You must talk to your doctor about your medical history, especially if you have any underlying health conditions such as heart disease, high blood pressure, liver or kidney disease, or if you take nitrates for chest pain or heart failure. Tadalafil may also interact with other medications, including certain antibiotics and certain antifungal drugs. Take Tadalafil exactly as it was prescribed for you. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

How to Use

Tadalafil is available in tablet form.

Do not crush or chew Tadalafil. Swallow it as a whole. If the tablet is not in your body, it should not be broken up into tablets. If it has been swallowed, it is not effective. Consult your doctor for medical advice.

Do not take Tadalafil with any of the following medications:

  • Nitrates (e.g. nitroglycerin, isosorbide) - used to treat chest pain
  • Other angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), used to treat high blood pressure
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), used to reduce pain and inflammation

Ask your doctor or pharmacist for a list of these medications if you are taking, or have recently taken, any of the following medications:

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    By Dr. R. A. Narayan

    In this article, Dr. Narayan, Head of Pharmacy and Medical Supervision at The University of British Columbia, explains the importance of consulting a healthcare professional before taking any medication.

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